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College of Liberal and Fine Arts

Deborah L. Mangold, Ph.D.

Associate Professor
Department of Psychology

Email: .(JavaScript must be enabled to view this email address)
Office: MH 4.02.44
Office hours: Not teaching this semester

Research area: Biological Psychology, Psychoneuroendocrinology, Stress, Psychopathology and Health

Additional Information
  • Biography

    Dr. Deborah L. Mangold received her B.S. in Psychology at The Johns Hopkins University, M.S. in Clinical Psychology at The Loyola College in Maryland and Ph.D. in Biological Psychology at Howard University.  Dr. Mangold’s doctoral dissertation focused on an examination of the effects of the opioid antagonist naloxone on the Hypothalamic-Pituitary-Adrenal (HPA) axis in non-dependent individuals with a family history of alcoholism.  Her doctoral thesis was completed under the direction of Dr. Gary Wand, in his laboratory at The Johns Hopkins University School of Medicine.

    Following the completion of her doctoral dissertation, Dr Mangold completed post-doctoral training in Neuroendocrinology and Human Genetics at the Brain Research Institute, The University of California, Los Angeles, in the laboratories of Dr. Anna Taylor and Dr. Ernest Noble.   Dr. Mangold joined the faculty of the Department of Psychology at UTSA in 2003 and is currently a member of the American Psychological Society, The Southwestern Psychological Society and the Research Society on Alcoholism.

    While at UTSA, Dr. Mangold’s program of research continues to focus on the HPA and opioid systems and has recently expanded to include investigations of the effects of genotype, acculturative stress and familial violence on neurohormonal, immune and health outcomes.


    • Postdoctoral Training, Endocrinology, Johns Hopkins University School of Medicine,
    • Postdoctoral Training, Brain Research Institute, University of California, Los Angeles
    • Ph.D. in Biological Psychology, Howard University
    • M.A. in Clinical Psychology, Loyola College
    • B.S. in Psychology, John Hopkins University
  • Recent Courses

    • 2513 Abnormal Psychology
    • 4183 Physiological Psychology
    • 4253 Psychology & Health
    • 7103 Adv Topics in Biopsychology (PhD level)
  • Research in Progress

    Biomarkers for Psychopathology Stress, Allostatic Load, and Health

  • Recent Publications

    • Wand, G. S., Mangold, D. L., ElDeiry, S., McCaul, M. E. & Hoover, D. (1998).  Family history of alcoholism and hypothalamic opioidergic activity. Arch Gen Psych, 55, 1114-1119.
    • Wand, G. S., Mangold, D. L., Ali, M. & Gigey, P. (1999).  Adrenocortisol responses and family history of alcoholism.  Alcoholism Clin Exp, 23, 1185-1190.
    • Wand, G. S., Mangold, D. L. & Ali, M. (1999).  Adrenocorticotropin responses to naloxone in sons of alcohol-dependent men.  J Clin Endodcrin and Metab, 84(19), 64-68.
    • Mangold, D. L., Peyrot, M., Gigey, P. & Wand, G. S. (2000).  Endogenous opioid activity is associated with obsessive-compulsive symptomatology in individuals with a family history of alcoholism.  Neuropsychopharmacology, 22(6), 595-607.
    • Mangold, D. L., McCaul, M. E., Ali, M. & Wand, G. S. (2000). Plasma adrenocorticotropin responses to opioid blockade with naloxone: Generating a dose response curve in a single session.  Biological Psychiatry, 48, 310-314.
    • Mangold, D. L. & Wand, G. S. (2006).  Cortisol and adrenocortioctropic hormone responses to Naloxone in subjects with high and low neuroticism. Biological Psychiatry 60, 850-855.Cortisol and ACTH Responses to naloxone in subjects with high and low neuroticism.
    • Mangold, D. L., Veraza, R., Kinkler L., and Kinney, N. (2007). Neuroticism predicts acculturative stress in Mexican-American college students. Hispanic Journal of Behavioral Sciences, 29 (3), 366-383.
    • Mangold, D. L., Wand, G. S., Javors, M. & Mintz, J. (2010). Childhood trauma, Acculturative stress and the cortisol awakening response in Mexican American adults. Hormones and Behavior, 58, 637-646.
    • Mangold, D. L., Marino, E. and Javors, M.  (in press). The cortisol awakening response predicts subclinical depressive symptomatology in Mexican Americans. J Psychiatric Research (in press).
    • Mangold, D. L., Mintz, J., Javors, M. & Marino, E. (in press). Neuroticism, acculturative stress, and the cortisol awakening response in Mexican Americans. Hormones and Behavior. 
    • Mangold, D.L. (under review).  Subclinical depressive symptomatology predicts inflammation in Mexican Americans.
    • Mangold, D.L. (under review).  Acculturative stress predicts inflammation in Mexican Americans.

    Published Proceedings

    • McCaul, M. E., Pickens, D. S. & Mangold, D. L. (1991, August).  Counselor-targeted interventions: Effects on client participation in drug treatment.  Proceedings of the Annual Convention of the American Psychological Association, San Francisco, CA  Pharmacology, Biochemistry and Behavior, 39, 24.
    • Ilgin, N., Eldeiry, S., Mangold, D. L., Dannals, H. T., Raver, W. B., Mathews, J. L., Musachio, J. L., McCaul, M., Wand, G. S. & Frost, J. J. (1997, June).  Measurement of brain mu opioid receptor binding in alcohol dependence by PET.  Proceedings of the 44th Annual Meeting for the Society of Nuclear Medicine, San Antonio, TX.  Journal of Nuclear Medicine, 12, (5) 115-116.
    • Mangold, D. L., Gigey, P., & Wand, G. S. (1998, May).  Enhanced sensitivity to opioid receptor blockade is associated with a family history of alcoholism.  Proceedings of the 21rst Annual Scientific Meeting of the Research Society on Alcoholism, Hilton Head, NC.  Alcoholism Clin Exp Res (suppl) 22 (3), 29a.
    • Mangold, D. L., Meyers, L., Ali, M., Gigey, P., Gotjen, D., Getz, K, & Wand G. S. (1999, May).  Opioid receptor blockade modulates type II behavioral symptomology in high risk, non-alcoholics.  Proceedings of the 22rst Annual Scientific Meeting of the Research Society on Alcoholism, Santa Barbara, CA.  Alcoholism Clin Exp Res (suppl) 23 (5), 38a.
    • Mangold, D. L., Getz, K., Gotjen, D., Hernandez-Avila, C., Kranzler, H., Myers, L. & Wand, G. S. (1999, May).  The effects of oral contraceptives on cortisol responses to naloxone in high risk women.  Proceedings of the 22nd  Annual Scientific Meeting of the Research  Society on Alcoholism.  Santa Barbara, CA.  Alcoholism Clin Exp Res, (suppl) 23 (5), 38a.
    • Bencherif, B., Ilgin, N., Wand, G. S., Eldeiry, S., Mangold, D. L., Musachio, J.L., Rafvert, H. T., Mathews, W. B., Dannals, R. F. & Frost, J. J. (1999, June).  Statistical parametric mapping of brain opioid receptor binding changes in chronic alcoholics.  Proceedings of the 46th Annual Meeting for the Society of Nuclear Medicine, Los Angeles, CA.  Journal of Nuclear Medicine, 40, (5) 110-111.
    • Mangold, D. L., Kalechstein, A., & Newton, T.  (2001, June).  A meta-analyses: Neuropsychological deficits associated with methamphetamine dependence.  Proceedings of the Annual Scientific Meeting of the College of Problems on Drug Dependence, Scottsdale, Arizona.
  • Selected Honors

    • Research Capacity Training Fellowship Award, Hispanic Association of Colleges and Universities
    • Shared Resource Scholar, Shared Resource Core, School of Nursing, University of Texas Health Science Center at San Antonio
    • Research Development Award ($3,000), Office of Research Development, University of Texas at San Antonio.
    • New Faculty Research Award ($5,000), Office of Research Development, University of Texas at San Antonio
    • NICDS Postdoctoral Training Award, Department of Neurobiology, University of California, Los Angeles

    Recent and Current Funding Awards

    • 9/05 - 8/08 Mangold, D.L. (Principal Investigator) R24-MH070636 01A1, NIMH: South Texas Initiative for Mental Health Research, Post Traumatic Stress Disorder and Health Problems in Mexican-American Women
    • 8/09 - 8/11  Mangold, D.L. (Principal Investigator), San Antonio Life Sciences Institute, Infrastructure Grant.
    • 9/08 - 9/11 Mangold, D.L. (Principal Investigator), UTSA Subcontract, U.S. Army Medical Research and Material Command, Office of the Congressionally Directed Medical Research Programs. Longitudinal Examination of the Effects of Neuroticism on Pre- versus Post-Deployment Changes in Hypothalamic Pituitary-Adrenal Axis reactivity, inflammation and Health

    Invited Presentations:

    • Mangold & Wand, G.S. (November, 2008). Neuroticism and morning salivary cortisol levels predict proinflammatory response in Mexican-Americans.   Presented at: A Brain Research Meeting: Stress, Coping and Disease, Arlington, VA.


    • Neuroscience Institute
    • Association for Psychological Science
    • Society for Biological Psychiatry
    • Southwestern Psychological Association
    • American Psychological Association

    Ad-hoc reviewing

    • Hormones and Behavior
    • Psychoneuroendocrinology
    • Biological Psychology
    • Journal of Psychosomatic Research
    • Biological Psychiatry
    • Journal Psychiatric Research